By F. S. Philips (auth.), Franco M. Muggia, Charles W. Young, Stephen K. Carter (eds.)
F. M. MUGGIA while confronted with the inadequacies of present melanoma therapy, we wish to examine what the long run might carry. often, we take with no consideration the earlier, who prefer examine into completely new components. notwithstanding, the chronic improvement of fertile soil may perhaps yield excellent rewards should you decide to construct at the wisdom of the past--hence, this symposium on anthracycline antibiotics. even though the anthracycline antibiotics signify a lot of the current and way forward for melanoma remedy, their real use c stretches again slightly twenty years to the pioneering efforts of Aurelio Di Marco, who characterised the antitumor homes of daunomycin and adriamycin. * The scientific software of those compounds heralded a decade of pleasure between oncologists facing pediatric tumors, breast melanoma, leukemias, and lymphomas, and opened new wish for sufferers with sar comas and various different tumors that were deemed - sistant to chemotherapy. those successes have been tempered with the belief that the antitumor impression of anthracyclines may be completed from time to time purely on the very excessive rate of risking cardiac decompensation and, virtually constantly, with the incidence of alopecia and different acute toxicities. This list of prior achievements and difficulties has slowly given approach to a gift more and more illuminated through our skill to switch the distressing toxicities of those brokers. particular medical reports supplemented via inventive laboratory types have steadily elucidated mechanisms and danger components im plicated within the cardiomyopathy.
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Extra info for Anthracycline Antibiotics in Cancer Therapy: Proceedings of the International Symposium on Anthracycline Antibiotics in Cancer Therapy, New York, New York, 16–18 September 1981
Sieber SM and Adamson RH. 1975. Toxicity of antineoplastic agents in man: Chromosomal aberrations, antifertility effects, congenital malformations and carcinogenic potential. Adv. l: 57-155. 4. Weisburger JH, Griswold jr. DP, Prejean JD, Casey AE, Wood jr HB,and Weisburger EK. 1975. The carcinogenic properties of some of the principal drugs used in clinical cancer chemotherapy. , 52 1 - 17 • 5. Bertazzoli C, Chieli T,and Solcia E. 1971. Different incidence of breast carcinomas or fibroadenomas in daunomycin or adriamycin treated rats.
1978. Cancer Treat. , 62, 1535. 27. Giuliani FC, Kaplan NO. 1980. , 40, 4682. 28. Di Marco A, Casazza AM, Gambetta R, Supino R, Zunino F. 1976. , 36, 1962. 28 29. Di Marco A, Casazza AM, Dasdia T, Necco A, Pratesi G, Rivolta P, Velcich A, Zaccara A, Zunino F. 1977. Chern. Biol. Interactions, ~, 291. 30. Arcamone F, Di Marco A, Casazza AM. 1978. Adv. Cancer Chemother. Japan Sci. Soc. Press, Tokyo and University Park Press, Baltimore, 297. 31. Formelli F, Casazza AM. 1981. 12th Int. , Florence, July 19-24, 1981, Abstracts, 114.
However, the high antitumor activity of OX against B16 melanoma, and also against some human melanomas transplanted in nude mice (18) is not paralleled by the clinical results. It is therefore of interest to know whether the selective antitumor activity observed in experimental studies with the anthracyclines here described will be observed and confirmed in humans. The second important observation in that cardiotoxicity can be dissociated from potency and from antitumor activity. Particularly interesting in this regards is 4'-deoxyOX, which is more potent than OX, more active against some solid tumors, and definitely less cardiotoxic.