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By Georges Mathé (auth.), Georges Mathé (eds.)

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Isolator, designed and used for rearing of germfree animals [30] and modified for patient isolation. Personnel remains outside the isolator, handling the patient by means of gloves. Air enters under overpressure through a high efficiency inlet filter, and leaves through a fluid trap or an outlet filter. Items are passed through a lock, which is kept as clean as possible by either ultraviolet lamps, and/or an outward high velocity stream of filtered air, or through a germicidal trap. [22]. Results obtained with this method of isolation with a mechanical barrier between patient and outside world are good [3,4, 17, 18, 19, 28].

Nitrogen mustard - Diminution of toxicity in axenic mice. Science 140, 1400-1401 (1963). 4. WILSON, B. : Survival studies of whole-body x-irradiated gum-free (axenic) mice. Radiat. Res. 20, 477-483 (1963). 5. GRISWOLD, D. , LASTER, W. , SNOW, M. , SCHABEL, F. , SKIPPER, H. : Experimental evaluation of potential anticancer agents. XII. Quantitative drug response of the SA 180, CA 755 and leukemia L 1210 systems to a "standard list" of "active" and "inactive" agents. Cancer Res. 23 (4) Part 2, 271-519 (1963).

J. Med. 44, 234-242 (1968). 10. , AMIEL, J. , SCHLUMBERGER, J. : Acute lymphoblastic leukemia treated with a combination of prednisone, vincristine, and rubidomycin. Value of pathogen-free rooms. Lancet 1967 II, 380-382. 11. MIKELSON, G. , HALBERT, M. , SORENSON, S. : Development of an open isolation system for the care of low resistance hospital patients. August 1968, Final Report Contract PH-43-65-999 NCI, NIH. 12. PREISLER, H. , HENDERSON, E. : Gastrointestinal sterilization procedures in patients with acute leukemia.

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