By Georges Mathé MD (auth.)
I want to thank all my co-workers who've collaborated with me, from 1963 beforehand, in organic and medical study within the box of melanoma lively immunotherapy, of its immuno prevention and immunorestoration. they're going to usually be quoted during this e-book. i'm rather thankful to those that have helped me to write down it through reviewing a few chapters: D. BELPOMME, J. F. DOR~, IRENE FLORENTIN, A. GOUTNER, I. J. Hm, R. HUCHET and MARIE-CHRISTINE SIMMLER. I additionally thank NICOLE VRIZ, MARIE-CLAUDE SCHNEIDER, FENELLARIsELEY and M. JUVET for his or her prepared and effective co-operation within the preperation of the manuscript. i'm ultimately thankful to all authors of books or articles who approved me to breed their figures or tables. Paris, April 1976 G. MAT~ Contents bankruptcy 1. creation and Definitions 1 bankruptcy 2. organic foundation: Tumour linked Antigens, the Immune equipment and Its Behaviour pertaining to melanoma Cells five 2. 1. Tumour-Associated Antigens five 2. 2. The Immune equipment 19 2. 2. 1. Humoral Mediated Immunity and telephone Mediated Immunity 19 2. 2. 2. T- and B-Lymphocyte and Monocyte Differen tiation 22 2. 2. three. T-Lymphocyte services 25 2. 2. four. B-Lymphocyte features 30 2. 2. five. Macrophage capabilities 31 2. 2. 6. K-Cell functionality 32 2. three. The Immune equipment and melanoma Cells 33 2. three. 1. Mechanisms serious about Tumour phone Rejec tion 33 2. three. 1. 1. In vivo facts for Tumour Immunity 33 2. three. 1. 2.
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Extra info for Cancer Active Immunotherapy: Immunoprophylaxis and Immunorestoration
30 Not all B-immunoblasts become plasma cells: some revert to lymphocytes which exert memory functions, just as some T-immunoblasts become memory-T-lymphocytes. this was shown in humoral responses by cell transfer experiments (MILLER and SPRENT, 1971). These B-memory cells could derive from an asymetric differentiation of B-lymphocytes (BYERS and SERCARZ, 1968), or by a return of antibody-producing cells to an undifferentiated state (NOSSAL and LEWIS, 1971). It has already been shown that B-lymphocytes require the help of T-lymphocytes before differentiating into antibody-forming cells in response to many antigens.
These cells undergo a variety of morphological and physiological alterations (NELSON, 1974; DAVID, 1974), and such activated macrophages are thought to be the effector cells in cell-mediated immunity. ,1972a). This latter action will be the object of a detailed analysis below. , 1971). , 1971, 1973). 6. K-Cell Function In addition to cytolytic T-lymphocytes and to macrophages, which can also display cytotoxic activity, evidence has recently been obtained that a third type of cell is involved in cell-mediated cytotoxicity, in vitro.
Bone marrow is the most likely site where this differentiation can take place in mammals (ABDOU and ABDOU, 1972; NOSSAL and PIKE, 1974). Recent studies have shown that bone marrow, in mice, contains B-cell precursors which are nondividing Igbaering cells with already restricted specificity. , 1972, 1973). Other authors have reported that a large fraction of bone marrow small lymphocytes bear neither T- nor B-Iymphocyte surface markers. These cells arise from dividing large lymphoid cells, which appear similar to the transitional B-cells of LAFLEUR e t ar.