Download Cancer Immunotherapy: Paradigms, Practice and Promise by Tyler J. Curiel (auth.), Tyler J. Curiel (eds.) PDF

By Tyler J. Curiel (auth.), Tyler J. Curiel (eds.)

This paintings will supply a historic point of view on tumor immunotherapy, speak about basic mechanisms of failed tumor rejection, examine passive thoughts to spice up anti-tumor immunity, in addition to have an in-depth examine lively concepts to spice up anti-tumor immunity.

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Cancer Res 55:3847–3853 62. Maeurer MJ, Martin DM, Castelli C, Elder E, Leder G, Storkus WJ, Lotze MT (1995) Host immune response in renal cell cancer: interleukin-4 (IL-4) and IL-10 mRNA are frequently detected in freshly collected tumor-infiltrating lymphocytes. Cancer Immunol Immunother 41:111–121 63. Tosolini M, Kirilovsky A, Mlecnik B, Fredriksen T, Mauger S, Bindea G, Berger A et al (2011) Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer.

How then, can B cells be prognostically good in one investigation of ovarian carcinoma while detrimental in another? First, patients in the latter study were subjected to chemotherapy (which can profoundly affect the numbers and functionality of immune cell subsets), while those in the former study were not. Second, the populations delineated by CD19 and CD20 are not precisely the same: while CD20 is present on the surface of all mature B cells236–238 and CD19 is predominantly expressed on B cells239, these surface markers have slightly different expression profiles.

Sfanos KS, Bruno TC, Maris CH, Xu L, Thoburn CJ, DeMarzo AM, Meeker AK et al (2008) Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing. Clin Cancer Res 14:3254–3261 91. Ye ZJ, Zhou Q, Gu YY, Qin SM, Ma WL, Xin JB, Tao XN et al (2010) Generation and differentiation of interleukin-17-producing CD4+ T cells in malignant pleural effusion. J Immunol 185:6348–6354 92. Derhovanessian E, Adams V, Hahnel K, Groeger A, Pandha H, Ward S, Pawelec G (2009) Pretreatment frequency of circulating IL-17+ CD4+ T-cells, but not Tregs, correlates with clinical response to whole-cell vaccination in prostate cancer patients.

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