Download Cancer in Transplantation: Prevention and Treatment: by Israel Penn (auth.), J. L. Touraine, J. Traeger, H. Bétuel, PDF

By Israel Penn (auth.), J. L. Touraine, J. Traeger, H. Bétuel, J. M. Dubernard, J. P. Revillard, C. Dupuy (eds.)

Malignancies are widespread issues in organ transplantation, in most cases because the results of an infection with yes viruses and of long term immunosuppression. The epidemiology confirms that the elevated prevalence matters definite cancers, specifically HIV-related epidermis cancers and EBV-related lymphoproliferative malignancies.
This booklet covers all at the moment on hand info in this very important subject of the relationships among transplantation and malignancies: preexisting cancers, posttransplant cancers, their etiology and pathophysiology, their prevention and therapy. an important a part of the quantity is dedicated to prophylaxis, early detection and sleek different types of remedy in posttransplant lymphomas. As a end of some of these new facts, the idea of immunosurveillance merits to be considerably modified.

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Additional resources for Cancer in Transplantation: Prevention and Treatment: Proceedings of the 27th Conference on Transplantation and Clinical Immunology, 22–24 May 1995

Sample text

Incidence of posttransplant De-Novo malignancies. 000 patients, transplant years 1985-1993 Type of tumor Melanoma Kaposi sarcoma Colon cancer Lung cancer Gallbladder/billiary tract Liver cancer Bladder cancer Kidney cancer Cadaver kidney transplants (n =59476) Heart transplants (n = 10987) Liver transplants (n =3113) 67 221 84 226 191 146 209 764 27 46 82 173 91 91 121 121 243 548 0 0 13 47 99 225 Multicenter analysis ofposttransplant malignancies 23 would seem unlikely that the differences in tumor incidence shown in Table 6 would be attributable entirely to the "strength" of immunosuppressive treatment.

2. Cervical carcinoma Physiopathology of this carcinoma have progressed recently. It has been shown that the vast majority of these cancers is related to the oncogenic effect of human papilloma viruses (HPV), in particular HPV types 16 and 18. Also these carcinomas are preceded by pre-cancerous lesions (cervical intra-epithelial neoplasia (CIN)) which can be detected by cervical cytology (Pap-smear) or colposcopy. Screening for cervical carcinoma is based on Pap-smear follow-up. Recent guide-lines have been published: screening should be performed between 20 to 65 years, and the interval between 2 cytology should be 3 years (after 2 normal pap-smears).

Bourneville-Pringle and angiomyolipomatosis ofthe kidneys and renal cancer, 1 patient with neuroblastoma of the kidneys and 1 patient with nephrotoxicity of cytotoxic drugs and retinoblastoma. 6 children were not transplanted, 3 because they died from the tumor and 3 were waiting for a transplant. 9 years after the diagnosis of tumor. 6 years after RTPL, all were continuously free from malignancy. 1 years after start of RRT still on dialysis. One boy with secondary polycystic kidney disease and renal carcinoma was cured after bilateral nephrectomy.

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