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By Fran Drescher

Along with her trademark humour, Fran tells of her indefatigable look for solutions and the melanoma analysis that she eventually beat. yet now not earlier than a goldmine of funny insights have been printed to her approximately what relatively issues such a lot in lifestyles.

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Although this antigen was found, for example, in embryonic tissues, it is possible that it may also be present in normal adult tissues and is indetectable with the methods available. Two types of antigens have been demonstrated with certainty as antigens appearing only in tumours, both of them have been shown for tumours induced by oncogenic viruses. It is the viral antigen appearing in tumours producing the virus and the so-called complement-fixing antigen CF A. The latter must be distinguished from the antigen which is known to be detectable by complement fixation tests in tumour tissues of various origin since 1927 (d.

E. KLEIN and SJOGREN (1960 b) obtained positive results only when tumours and immune cells were mixed in vitro prior to inoculation. In experiments on neutralization of tumour cells by immune cells from regional lymph nodes OLD et al. (1962) observed a similar situation as SLETTENMARK and KLEIN. If peritoneal cells from hyperimmunized animals were used, the proportion of 3 immune cells per tumour cell was sufficient to obtain positive results. Histochemical reactions showed that more than 501)/0 of the cells used were macrophages.

SHIUZO ISOJIMA and GRAHAM (1958) studied the effect of immunization on the development of mammary tumours in mice of the C3H strain. In the first experiment, with 22 mice, the spontaneous tumours were surgically removed and a small portion of them was left in the wound. The excised tumours were suspended in FREUND'S adjuvant. Twenty-seven control mice were given FREUND'S adjuvant alone. In experimental mice, the re-occurrence of tumour was significantly retarded. The authors believed that if a similar immunization were performed before the tumours started to develop, the incidence of tumours should decrease.

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