Download Cancer Therapy: New Trends by Ch. Herfarth, P. Schlag (auth.), Prof. Dr. Peter Bannasch PDF

By Ch. Herfarth, P. Schlag (auth.), Prof. Dr. Peter Bannasch (eds.)

In greater than 20 contributions new traits in melanoma treatment are reviewed and seriously mentioned by means of hugely powerfuble authors. Their contributions are in keeping with a world symposium and canopy all significant fields of scientific oncology. precise emphasis is given to surgical oncology (including photodynamic laser remedy and radiosurgery), radiation oncology, hyperthermia, new antineoplastic brokers, enzyme-pattern-targeted chemotherapy, drug resistance, organic reaction modifiers, bone marrow transplantation, antibody guided treatment, induction of telephone differentiation in reworked cells, and the individualization of tumor remedy. The stimulating dialogue on the finish of every part protecting those issues will particulary profit the medical oncologist and all researchers dedicated to the development of melanoma therapy.

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This concept is, however, somewhat misleading since repair - even much more repair - occurs in tissues where c1onogenic survival of stem cells is not the primary cellular mechanism leading to functional or structural failure of the irradiated organ. Repair can be precisely measured in cells, in tissues, in tumors but we do not know what repair actually is; moreover, it probably reflects very different molecular and cellular mechanisms in different tissues of the body. I just cannot believe that the increased tolerance of the brain to fractionated radiotherapy should be due to the same molecular DNA repair mechanism which allows irradiated bacteria to continue proliferating rapidly.

Development of heavy-ion therapy programs is justified for some types of tumor requiring a combination of high-LET radiation and a high degree of physical selectivity. References Austin-Seymour M, Urie M, Muzenrider J, Willett C, Goitein M, Verhey L, Gentry R, McNulty P, Koehler A, Suit H (1988) Considerations in fractionated proton radiation therapy: clinical potential and results. Radiother Oncol (in press) Castro JR, Gademann G, Collier JM, Linstad D, Pitluck S, Woodruff K, Gauger G, Chard D, Gutin Ph, Phillips ThL, Chu W, Henderson Sh (1987) Strahlentherapie mit schweren Teilchen am Lawrence Berkeley Laboratory der Universitat von Kalifomien.

The principle of this old idea (Takahashi 1964) is shown in Fig. 8. The collimator consists of two sets of thin steel or tungsten leaves which can be moved independently and adjusted in such a way that the opening in the collimator matches the outline of the target volume from the beam's eye view. The first multi-leaf collimators had to be adjusted manually, which was a cumbersome task and hampered the practical applicability of these systems. A completely computer-controlled multi-leaf collimator is under development at the mechanical workshop of the German Cancer Research Center (Pastyr et al.

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