By Tuula T. Teeri, Birte Svensson, Harry J. Gilbert
(Royal Society of Chemistry) Royal Institute of know-how, Stockholm, Sweden. The complaints of the 4th Carbohydrate Bioengineering assembly hung on June 10-13, 2001, on the Royal Institute of expertise, Stockholm, Sweden. For researchers and practitioners in medication, chemical, nutrition, and pharmaceutical components.
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Extra resources for Carbohydrate Bioengineering Interdisciplinary Apporaches
I ,3. Binding of Lactose and the Acceptor Analogue 4-Fluoro-4-deoxylactose. Recently, structures of LgtC and UDP-2FGal in complex with lactose, the real acceptor, was solved, as well as the complex with the acceptor sugar analogue 4-fluoro-4deoxylactose. These compounds that have chemical groups at their 4’positions (OH for lactose and F for the analogue) bind in identical manner to the previously discussed analogue 4-deoxylactose. However, a chemical group present at this position seems to distort the galactosyl moiety of the donor.
Highly hydrated HA also promotes cell locomotion and migration which are very prominent in embryogenesis, wound healing and malignancy, processes characterized by rapid increase of HA. Hyaluronidases, the enzymes which degrade hyaluronic acid, are widely spread in nature and have a wide range of pH optima. They have been classified in three major groups based on their mechanism and substrate specificity, deduced from biochemical analysis of enzymes and their reaction products3. 35) found in testis and lysosomes, as 20 Carbohydrate Bioengineering: Interdisciplinary Approaches well as in the venom of bees, wasps, snakes and scorpions.
6) ... I D W E ... I D F E D l l l - . 5) 26 Carbohydrate Bioengineering: Interdisciplinary Approaches osteo- and rheumatoid arthritis, probably by the structure-based design of specific inhibitor (s). Hya is a potent major allergen of bee venom and the knowledge of the structural determinants responsible for the allergenic potency of Hya is expected to have important clinical implications. A promising approach is t o inhibit the onset of an allergic reaction, which is triggered by binding of allergen to specific patient IgEantibodies.