By Chiaho Shih
The scope of the publication is especially wide, protecting a variety of components in HBV/HDV and HCV study, together with either simple and medical technological know-how. the chosen themes variety from epidemiology, immunology, molecular virology and oncology, to medical remedy.
Chronic Hepatitis B and C involves 14 chapters, every one being a overview of a distinct subject on HBV or HCV. whereas evaluate articles on a different subject are available in periodical journals, they generally tend to be extra limited in presentation. hence, this e-book will offer extra in-depth assurance of what are provided as "unpublished effects" and "data now not proven" in magazine articles. in addition, numerous authors during this booklet don't write evaluate articles usually. a few authors wrote experiences on a selected subject usually, yet they attempted a brand new subject during this ebook (e.g., Dr. YF Liaw on ordinary course," Dr. Shih on "virion release," Dr. Michael Lai on "lymphotropism of HCV," and so forth ... ). total, the ebook will provide invaluable details on the slicing age.
Readership: Researchers in virology, infectious illnesses and melanoma medicine.
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Additional info for Chronic Hepatitis B and C : Basic Science to Clinical Applications
Many long-term follow-up studies have shown that individuals with HBV and HIV coinfection tend to have higher levels of HBV DNA, lower serum ALT levels and lower rates of spontaneous HBeAg seroconversion. 74 The development of effective antiretroviral regimen has led to immune reconstitution in many HIV-infected patients. 1 Whether this rate is higher in perinatally acquired infection because of the longer duration of infection than adult-acquired infection remains unknown. 76 The annual incidence and cumulative probability of cirrhosis in patients with chronic HBV infection varied considerably in different reported series, possibly due to inclusion of patients in different phases of infection as well as the variable severity of liver injury in each phase.
Liaw YF, Lin DY, Chen TJ, Chu CM. (1989) Natural course after the development of cirrhosis in patients with chronic type B hepatitis: a prospective study. Liver 9: 235–241. 86. Liaw YF, Chen JJ, Chen TJ. (1990) Acute exacerbation in patients with liver cirrhosis: a clinicopathological study. Liver 10: 177–184. 87. Fattovich G, Bortolotti F, Donato F. (2008) Natural history of chronic hepatitis B: special emphasis on disease progression and prognostic factors. J Hepatol 48: 335–352. 88. Liaw YF.
Hepatl Int 2: 263–283. 15. Chu CM, Liaw YF. (1987) Intrahepatic distribution of hepatitis B surface and core antigens in chronic hepatitis B virus infection. Hepatocyte with cytoplasmic/membranous hepatitis B core antigen as a possible target for immune hepatocytolysis. Gastroenterology 92: 220–225. 16. Hui CK, Leung N, Yuen ST, et al. (2007) Natural history and disease progression in Chinese chronic hepatitis B patients in immune-tolerant phase. Hepatology 46: 395–401. 17. Chu CM, Yeh CT, Lee CS, et al.