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By Henryk Dancygier

Clinical Hepatology – rules and perform of Hepatobiliary illnesses presents transparent and complete assurance of the etiology, mechanisms of disorder, prognosis, and sensible administration of the total spectrum of liver and biliary problems. It additionally offers a great, evidence-based overview of the speedily increasing box of hepatobiliary diseases.

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Extra info for Clinical Hepatology: Principles and Practice of Hepatobiliary Diseases

Example text

Nucleus The hepatocyte nucleus comprises 5–10% of the cell volume. It is round and contains one or several nucleoli (Fig. 9). These are regions of dense RNAcontaining granules and fibrils embedded in a protein matrix. The nuclear contents are kept separate from the cytoplasm by a nuclear membrane. This doublemembrane contains pores which allow macromolecules to cross in a two-way process. The outer sheet of the nuclear membrane is studded with ribosomes. The space between the inner and outer membrane (perinuclear space) is in straight continuity with the rough endoplasmic reticulum.

From here the lymph flows to the space of Mall that is situated in direct proximity to the portal tract, between the peripheral edge of the portal connective tissue and the first plate of periportal hepatocytes. From the space of Mall the lymph enters the portal capillary lymphatics and then leaves the liver through increasingly wider lymph vessels and three groups of lymph nodes: the portal (hilar), central (situated in the region of the hepatic veins orifices) and parietal (capsular) lymph nodes.

The fluid reaches the duodenum through a system of communicating ducts whose diameter increases gradually from the liver to the duodenum. The smallest units are the bile canaliculi which are formed by apical microvillous processes of two or three adjacent hepatocytes. They may be well-visualized on light microscopy by immunohistochemistry using polyclonal antibodies against carcinoembryonic antigen (CEA) (Figs. 6) [12]. The pericanalicular cytoplasm represents a specialized region of the hepatocyte that is responsible for the shape of the canaliculi.

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