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By Joydeep Basu

This e-book summarizes contemporary advancements in tissue engineering and regenerative drugs with an emphasis on commercialization and product improvement. It emphasizes the good points of present mobilephone remedy and tissue engineered items that experience facilitated winning commercialization and highlights roadblocks to profitable product improvement. Chapters talk about preclinical and medical checking out, regulatory, quality controls, production matters, producing and securing highbrow estate. The authors current a whole “how to” guide for the improvement of tissue engineered and regenerative medication items from conceptualization to medical trial to production.

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16. Aliotta JM, Sanchez-Guijo FM, Dooner GJ, et al. (2007) Alteration of marrow cell gene expression, protein production and engraftment into lung by lung derived micro-vesicles: a novel mechanism for phenotype modulation. Stem Cells 25: 2245–56. 17. Baer PC, Bereiter-Hahn J, Missler C, et al. (2009) Conditioned medium from renal tubular epithelial cells initiates differentiation of human mesenchymal stem cells. Cell Prolif 42: 29–37. 18. Mack GS (2011) Cephalon splashes out on mesenchymal stem cells.

The cell is the primary active biological ingredient in TE/RM. In this chapter, we examine the principal classes of stem and progenitor and committed cell populations currently under active commercial development for application in TE/RM. We highlight what features of these cell populations make them amenable to successful commercialization and discuss the possible mechanisms of action by which they present therapeutic potential. Additionally, we point out aspects of their phenotype and function that may impede their successful negotiation of the regulatory approval process.

23. Ben-David U, Benvenisty N, Mayshar Y (2010) Genetic instability in human induced pluripotent stem cells: classification of causes and possible safeguards. Cell Cycle 9: 4603–4. 24. com 25. Basu J, Willard HF (2005) Artificial and engineered chromosomes: nonintegrating vectors for gene therapy. Trends Mol Med 11: 251–8. 26. Sheridan C (2011) Gene therapy finds its niche. Nat Biotechnol 29: 121–8. 27. Stevanato L, Corteling RL, Stroemer P, et al. (2009) c-MycERTAM transgene silencing in a genetically modified human neural stem cell line implanted into MCAo rodent brain.

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