By Chris A. Liacouras, Jonathan E. Markowitz
This quantity offers a background of Eosinophilic Esophagitis (EoE), a easy realizing of the body structure of the eosinophil, and a present realizing of the pathophysiology and genetics of EoE. The emphasis is on medical purposes together with featuring indicators, prognosis and healing procedures for sufferers with EoE. Written through either pediatric and grownup specialists within the fields of gastroenterology, allergic reaction and pathology, this quantity comprises the freshest details. delivering useful details valuable within the therapy of sufferers, this publication could be of significant worth to gastroenterologists, allergists, pathologists, clinical citizens, fellows, internists, and common practitioners who deal with sufferers with eosinophilic esophagitis.
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Additional resources for Eosinophilic Esophagitis (Clinical Gastroenterology)
A. E. OTABLY ESOPHAGEAL EOSINOPHILIA IS NOT EXCLUSIVELY LIMITED TO %O% )N PARTICULAR EOSINOPHILIC INlLTRATION OF THE DISTAL PART OF THE ESOPHAGUS HAS BEEN REPORTED IN PATIENTS HAVING GASTROESOPHAGEAL REmUX DISEASE '%2$ %SOPHAGEAL EOSINOPHILIA THEREFORE REQUIRES A PROCESS OF DIFFERENTIAL DIAGNOSIS AND CANNOT A PRIORI BE EQUATED WITH EOSINOPHILIC ESOPHAGITIS ;4]. 1). FRICA THERE SEEMS TO BE A BROAD DISTRIBUTION OF THE DISEASE WORLDWIDE 3EVERAL STUDIES HAVE ADDRESSED THE INCREASING INCIDENCE AND PREVALENCE OF %O% IN THE ADULT POPULATION DURING THE LAST DECADES 4HREE OF THESE STUDIES THAT EVALUATED GEOGRAPHICALLY CONlNED REGIONS WILL BE DISCUSSED HERE ;6n8].
S A CONSEQUENCE OF %O%S MALE PREDILECTION IT IS NOT SURPRISING THAT FOOD IMPACTION OCCURS MORE FREQUENTLY IN MEN ;15, 24]. Interestingly, patients undergoing UPPER ENDOSCOPY FOR THE DIAGNOSTIC WORK
UP OF DYSPHAGIA OR FOOD IMPACTION ARE REPORTED HAVING %O% WITH A PREVALENCE OF n AND AN EVEN HIGHER RISK IF THE AGE YEARS ;12, 13= +APEL ET AL DESCRIBE AN INCREASING PREVALENCE OF %O% IN PATIENTS HAVING DYSPHAGIA WHICH ROSE FROM IN TO IN ;9].
Conversely, esophaGEAL MUCOSAL EOSINOPHILIA OCCURS AS A RESULT OF ACID REmUX DISEASE AND CAN BE reversed with acid-suppressant medications . Disruption of the Esophageal Epithelial Barrier Contributes to EoE $ILATED INTERCELLULAR SPACES HAVE BEEN IDENTIlED IN ADULTS WITH NON
EROSIVE REmUX DISEASE ALLOWING THE POSSIBILITY THAT REmUX
RELATED INCREASED INTERCELLULAR PERMEABILITY MAY EXPOSE THE ESOPHAGEAL MUCOSA TO UNPROCESSED DIETARY ANTIGENS ;53]. Furthermore, microarray transcriptional studies from esophageal mucosal biopsies have identiﬁed overrepresented ﬁlaggrin loss-of-function mutations in a population of EoE patients when compared to healthy controls .