Download Ethanol and the Liver: Mechanisms and Management by David Sherman, Ronald Ross Watson PDF

By David Sherman, Ronald Ross Watson

Distilling the on hand wisdom on ethanol-induced liver harm and without delay complementing the on hand bio-medical literature, Ethanol and the Liver covers pathogenic and scientific points of alcoholic liver affliction. offering broader assurance of the topic than any to be had monograph, the editors and their panel of specialists relate simple technology to pathogenesis and therapy modalities and discover destiny advancements.

Coverage includes:

  • Histopathology-fatty liver, alcoholic hepatitis, and cirrhosis
  • Ethanol metabolism and its consequences
  • Mechanisms within the pathogenesis of ALD, together with genetics, immunology, and insulin-like progress factors
  • Extrahepatic results of ALD and the function of alcohol in potentiating liver harm because of different etiologies
  • Interaction of alcohol with viral hepatitis
  • Epidemiology, analysis, and treatment
  • Management concepts, together with transplantation

    The large quantity of information and services amassed during this booklet make it an unprecedented resource.

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    Additional resources for Ethanol and the Liver: Mechanisms and Management

    Sample text

    2 Triacylglycerol synthesis (R=acyl group). 3 The principal reactions of fatty acid oxidation. Carnitine transferase (reaction 2) is responsible for transport across the outer mitochondrial membrane. being the committed step. This is followed by the sequential addition of two carbon units derived from acetyl CoA until the 16 carbon fatty acid palmitate is formed. This elongation process is carried out by the fatty acid synthetase complex. Further elongation and the insertion of double bonds to synthesize unsaturated fatty acids are carried out by other enzyme systems.

    1991). Polymorphonuclear leukocytes frequently surround and sometimes even penetrate hepatocytes containing MBs (“satellitosis”). Other morphologic features include apoptotic bodies, giant mitochondria in hepatocytes, cholestasis, siderosis, Kupffer cell enlargement and proliferation (activation), and infiltration to a variable degree by mononuclear cells (lymphocytes). Fibrosis may be minimal, perivenular and pericellular in zone 3 (central sclerosis), but also extensive with formation of fibrous septa, finally resulting in cirrhosis.

    This revealed evidence for chronic lipid peroxidation within the liver and the proposal that the mere presence of oxidizable fat within the liver triggers lipid peroxidation and may be a common mechanism for progression to other pathological entities such as steatohepatitis. , 1965). The same study showed a return to normal liver histology following 1 month abstinence. The best treatment therefore is abstinence from alcohol. , 1997). There is also evidence that exercise in rats prevents ethanol-induced fatty liver as compared to sedentary ethanol fed rats (Trudell, 1995).

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