The one evidence-based source combining gastroenterology and hepatology, this significant textbook significantly appraises the facts for analysis, screening, and remedy of gastrointestinal and hepatic illnesses, and gives transparent thoughts for administration.
a different characteristic is the grading of either the facts (randomized managed trials, systematic studies, or decrease caliber trials) and the remedy ideas. This constitution offers the reader with necessary counsel on implementation.
The 3rd version has been absolutely revised, delivering the latest reviews of the proof. it's also superior with new themes that experience major facts for therapy, together with;
- Esinophilic esophagitis
- Acute dysenteries
- Prevention and therapy of guests’ diarrhoea
- Frequency of inauspicious drug results on bowel functionality
- Management of hepatitis B
- Management of Hepatitis C
- Vascular sickness of the liver
- Non invasive prognosis of liver fibrosis
- Drug prompted liver affliction
Chapter 1 creation (pages 1–15): John WD McDonald, Andrew okay Burroughs, Brian G Feagan and M Brian Fennerty
Chapter 2 Gastroesophageal Reflux ailment (pages 17–61): Naoki Chiba and M Brian Fennerty
Chapter three Barrett's Esophagus (pages 62–77): Constantine A Soulellis, Marc Bradette, Naoki Chiba, M Brian Fennerty and Carlo A Fallone
Chapter four Esophageal Motility problems: Achalasia and Spastic Motor problems (pages 78–92): Jason R Roberts, Marcelo F Vela and Joel E Richter
Chapter five Eosinophilic Esophagitis (pages 93–101): Elizabeth J Elliott
Chapter 6 Ulcer sickness and Helicobacter pylori an infection: Etiology and therapy (pages 102–138): Naoki Chiba
Chapter 7 Non?Steroidal Anti?Inflammatory Drug?Induced Gastro?Duodenal Toxicity (pages 139–164): Alaa Rostom, Katherine Muir, Catherine Dube, Emilie Jolicoeur, Michel Boucher, Peter Tugwell and George Wells
Chapter eight Acute Non?Variceal Gastrointestinal Hemorrhage: therapy (pages 165–189): Nicholas Church and Kelvin Palmer
Chapter nine useful Dyspepsia (pages 190–199): Sander Veldhuyzen van Zanten
Chapter 10 Celiac sickness: prognosis, remedy and diagnosis (pages 200–210): James Gregor and Michael Sai Lai Sey
Chapter eleven Crohn's disorder (pages 211–231): Brian G Feagan and John WD McDonald
Chapter 12 Ulcerative Colitis (pages 232–247): Derek P Jewell, Lloyd R Sutherland, John WD McDonald and Brian G Feagan
Chapter thirteen Pouchitis after Restorative Proctocolectomy (pages 248–256): Darrell S Pardi and William J Sandborn
Chapter 14 Microscopic Colitis: Collagenous and Lymphocytic Colitis (pages 257–266): Johan Bohr, Robert Lofberg and Curt Tysk
Chapter 15 Drug?Induced Diarrhea (pages 267–279): Bincy P Abraham and Joseph H Sellin
Chapter sixteen Metabolic Bone affliction in Gastrointestinal issues (pages 280–300): Ann Cranney, Alaa Rostom, Catherine Dube, Rachid Mohamed, Peter Tugwell, George Wells and John WD McDonald
Chapter 17 Colorectal melanoma in Ulcerative Colitis: Surveillance (pages 301–310): Paul Collins, Bret A Lashner and Alastair JM Watson
Chapter 18 Colorectal melanoma: inhabitants Screening and Surveillance (pages 311–323): Theodore R Levin and Linda Rabeneck
Chapter 19 Prevention and remedy of tourists' Diarrhea (pages 324–334): Herbert L DuPont
Chapter 20 Clostridium Difficile linked ailment: analysis and remedy (pages 335–354): Lynne V McFarland and Christina M Surawicz
Chapter 21 Irritable Bowel Syndrome (pages 355–376): Alexander C Ford, Paul Moayyedi and Nicholas J Talley
Chapter 22 Ogilvie's Syndrome (pages 377–384): Michael D Saunders
Chapter 23 Gallstone affliction (pages 385–395): Laura VanderBeek, Calvin HL legislation and Ved R Tandan
Chapter 24 Acute Pancreatitis (pages 396–414): Colin D Johnson and Hassan Elberm
Chapter 25 weight problems administration: issues for the Gastroenterologist (pages 415–434): Leah Gramlich, Marilyn Zeman and Arya M Sharma
Chapter 26 Hepatitis C (pages 435–447): Keyur Patel, Hans L Tillmann and John G McHutchison
Chapter 27 Hepatitis B: diagnosis and remedy (pages 448–464): Piero Luigi Almasio, Calogero Camma, Vito Di Marco and Antonio Craxi
Chapter 28 Alcoholic Liver ailment (pages 465–474): Helene Castel and Philippe Mathurin
Chapter 29 Non?Alcoholic Fatty Liver disorder (pages 475–483): Christopher P Day
Chapter 30 Hemochromatosis (pages 484–492): Gary P Jeffrey and Paul C Adams
Chapter 31 Wilson's illness (pages 493–507): James S Dooley and Aftab Ala
Chapter 32 fundamental Biliary Cirrhosis (pages 508–523): Gideon M Hirschfield and E Jenny Heathcote
Chapter 33 Autoimmune Hepatitis (pages 524–532): Michael MP Manns and Arndt Vogel
Chapter 34 basic Sclerosing Cholangitis (pages 533–553): Nishchay Chandra, Susan N Cullen and Roger W Chapman
Chapter 35 Non?Histological review of Liver Fibrosis (pages 554–561): Dominique Thabut and Marika Simon?Rudler
Chapter 36 Portal Hypertensive Bleeding (pages 562–602): Christos Triantos, John Goulis and Andrew okay Burroughs
Chapter 37 Hepatic Outflow Syndromes and Splanchnic Venous Thrombosis (pages 603–618): Marco Senzolo, Neeral Shah, David Patch and Stephen Caldwell
Chapter 38 Ascites, Hepatorenal Syndrome and Spontaneous Bacterial Peritonitis (pages 619–635): Pere Gines, Andres Cardenas, Vicente Arroyo and Juan Rodes
Chapter 39 Hepatic Encephalopathy: therapy (pages 636–649): Peter Ferenci and Christian Muller
Chapter forty Hepatocellular Carcinoma (pages 650–660): Massimo Colombo and Massimo Iavarone
Chapter forty-one Fulminant Hepatic Failure: therapy (pages 661–684): James O'Beirne, Nicholas Murphy and Julia Wendon
Chapter forty two Liver Transplantation: Prevention and remedy of Rejection (pages 685–723): Maria Pleguezuelo, Giacomo Germani and Andrew ok Burroughs
Chapter forty three Liver Transplantation: Prevention and therapy of an infection (pages 724–739): Antoni Rimola and Miquel Navasa
Chapter forty four administration of HCV an infection and Liver Transplantation (pages 740–747): Brett E Fortune, Hugo R Rosen and James R Burton
Chapter forty five administration of HBV an infection and Liver Transplantation (pages 748–761): Evangelos Cholongitas and George V Papatheodoridis
Chapter forty six Liver Biopsy (pages 762–770): Evangelos Cholongitas, Andrew ok Burroughs and Amar P Dhillon
Chapter forty seven Drug prompted Liver affliction: Mechanisms and analysis (pages 771–786): Raul J Andrade and M Isabel Lucena
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Extra resources for Evidence-Based Gastroenterology and Hepatology, Third Edition
With a more stringent definition for a positive test of total symptom relief, the sensitivity of omeprazole to diagnose reflux was lower at 48–59%, compared with 6–19% for placebo. However, the specificity of the test was also low, and actually was higher with placebo than with omeprazole. Thus, the test in this study was more useful for ruling out the diagnosis than for ruling it in. Even patients who did not have GERD by definition had better symptom relief with omeprazole than with placebo. These may be patients with an acid sensitive esophagus who respond well to acid suppression despite their esophageal pH being within normal limits.
The authors concluded that the diagnosis of GERD could be ruled out if a patient failed to respond to a short course of high dose PPI. Fass et al.  also used an omeprazole 60 mg daily test versus placebo in GERD positive (35/42, 83%) and GERD negative patients (17%). 1%. Economic analysis revealed that the omeprazole test saved US$348 per average patient evaluated, with 64% reduction in the number of upper endoscopies and a 53% reduction in the use of pH testing. Most studies have used omeprazole in the “PPI test”.
The SF-36, QoL parameters for bodily pain and vitality also significantly improved. In the group with a negative SI only one patient clearly improved. 29 PA RT I Gastrointestinal disorders Thirty-three consecutive patients with symptoms of reflux, abnormal pH studies, but normal endoscopies were sequentially allocated to receive ranitidine 150 mg twice daily, omeprazole 40 mg once daily, or omeprazole 40 mg twice daily for 7–10 days . On the last day of treatment an esophageal pH study was repeated, and the results were correlated with symptoms.