By Edward Edelson
Solid technological know-how booklet at the topic, very thorough biographies of either Crick and Watson. textual content is a bit dry, however the occasioanl photo perks it up. Illustrations are in black and white. i'd suggest this booklet to the seventh grade up, and may contain a suggestion for the lecturers in addition.
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Additional info for Francis Crick and James Watson: And the Building Blocks of Life (Oxford Portraits in Science)
As far as it went, this was a good idea, but Watson and Crick knew they would not be home free until they could build a complete model that satisfied all the chemical and structural requirements. ” Crick eventually named his family’s house in Cambridge the Golden Helix and put a brass helix on the front of it. ” Years later, Watson was asked to give a talk to a small, exclusive club of scientists at Cambridge. After having a few drinks, he gave his talk coherently until the very end, when he came to sum up.
The difference between them is the location of just one hydrogen atom, but that is enough to change the size of the base. In Watson’s original model, the bases had the enol form. Donohue told Watson about new scientific evidence that the bases were much more likely to have the keto form. That information solidified the case for adenine-purine base binding in the DNA molecule. Having the bases in the keto form means that the cytosine-guanine bond is triple while the thymine-adenine bond is double, so that the pairs always match correctly.
This finding showed that DNA, not protein, was the carrier of phage genetic information. Watson later summed up the finding by saying that DNA was “the hat inside the hatbox,” with protein serving just as the virus’s container for the DNA. Such work raised the immediate question of how DNA carried genetic information. What in the structure of DNA made it possible for it to transmit all the traits of a living thing from generation to generation? And this question raised a further one: What made it possible for the changes called mutations to occur in the genetic makeup of an organism, as, for example, when a virus or a bacterium developed resistance to a drug?