Download Genetically Engineered Mice for Cancer Research: design, by Thomas Doetschman, L. Philip Sanford (auth.), Jeffrey E. PDF

By Thomas Doetschman, L. Philip Sanford (auth.), Jeffrey E. Green, Thomas Ried (eds.)

Genetically-engineered mouse types for melanoma study became worthy instruments for learning melanoma biology and comparing novel healing techniques. This quantity specializes in cutting-edge tools for producing, examining and validating such versions for learning elements of human melanoma biology. also, those types are rising as very important pre-clinical platforms during which to check melanoma prevention and healing options which will decide upon compounds for trying out in medical trials.

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Extra resources for Genetically Engineered Mice for Cancer Research: design, analysis, pathways, validation and pre-clinical testing

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5 kb In such cases, it is beneficial to keep the neo gene in ES cells, and remove it later in mutant mice after its physiological impact is assessed. Currently, four approaches have been developed in case the neo gene needs to be removed from the conditional knockout allele in mice. Xu et al. described two approaches to delete ploxPneo from mice. The first approach is to cross the mice containing the 3-loxP mutant allele with the EIIa-Cre transgenic mice (Lakso et al. 1996), and the second one is to microinject the Cre expression construct into the pronucleus of fertilized eggs (Xu et al.

Described two approaches to delete ploxPneo from mice. The first approach is to cross the mice containing the 3-loxP mutant allele with the EIIa-Cre transgenic mice (Lakso et al. 1996), and the second one is to microinject the Cre expression construct into the pronucleus of fertilized eggs (Xu et al. 2001b). The third method removes the floxed 2 The Use of Cre–loxP Technology and Inducible Systems to Generate Mouse… 21 Fig. 3 Strategies for the removal of the neo gene from the conditional knockout allele.

2001c). Recent studies revealed that increased insulin/IGF signaling (Shukla et al. 2006), activation of estrogen/ER-alpha signaling (Li et al. 2007; Jones et al. 2008), and increased expression of angiogenic factors, including angiopoietin-1 (Furuta et al. 2006) also facilitate breast cancer formation in BRCA1-deficient mice. 4 Cre–loxP-Mediated Gene Activation Another important application of the Cre–loxP system in cancer research is to achieve gene activation. Many human cancers are caused by activation of numerous oncogenes; for example, activating mutations of the RAS oncogene are found in approximately one-third of all human cancers (Bos 1989; Khosravi-Far and Der 1994).

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