By G.G. Delaini, Tomas Skricka, Gianluca Colucci, John Nicholls
Summary Colorectal melanoma (CRC), the 3rd so much known melanoma worldwide,imposes an important fiscal and humanitarian burden on sufferers and society.Nearly 10% of all melanoma occurrence world wide is CRC, and it's the merely significant malignancywith an identical incidence in women and men. on account that CRC is usually a diseaseof the aged, its fiscal burden is predicted to develop within the close to destiny, mostly dueto inhabitants getting older.
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A field with fewer than five budding foci is viewed as negative ; one with five or more buds is viewed as positive . Nonetheless, the intensity of tumor budding also seems to be important . Recent evidence suggests that tumor budding is associated with both lymphatic invasion and nodal metastases [75,78,79]. A number of 0 to 9 foci are classified as a low-grade or low“intensity” tumor budding, while 10 or more buds are a high-grade or high-“intensity” tumor budding . Higher intensity of tumor budding is significantly associated with higher risk of postoperative recurrence .
78. Tanaka M, Hashiguchi Y, Ueno H, et al (2003) Tumor budding at the invasive margin can predict patients at high risk of recurrence after curative surgery for stage II, T3 colon cancer. Dis Colon Rectum 46:1054–1059. 37 79. Ueno H, Murphy J, Jass JR, et al (2002) Tumour ‘budding’ as an index to estimate the potential of aggressiveness in rectal cancer. Histopathology 40:127–132. 80. Park KJ, Choi HJ, Roh MS, et al (2005) Intensity of tumor budding and its prognostic implications in invasive colon carcinoma.
On gross examination of the resection specimens, it is important to identify the actual polypectomy site. If the resection is performed within approximately 10 days post-polypectomy, the polypectomy site will usually be apparent as an area of erosion, ulcer, or induration. When resections are performed more than 10 days post-polypectomy, it is often difficult to identify the polypectomy site, which has probably healed and re-epithelialized. In a fresh unfixed specimen, if the polypectomy site is not grossly obvious, the pathologist, by careful palpation, can often find an area of induration that corresponds to the polypectomy site.