Download Lung Cancer Therapy Annual: 2 by Paul A Bunn, Heine H Hansen PDF

By Paul A Bunn, Heine H Hansen

Lung melanoma treatment Annual outlines key features in early prognosis, type and staging, and reports extensive the present literature, discussing the most recent advancements in remedy and summarizing the newest facts within the box of chemotherapy and biologic treatment

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8% (10 of 48) of the patients who were allocated to limited disease would have been judged to have had extensive disease. Pelosi et al74 investigated the impact of tumor cell immunodetection in the bone marrow on survival of patients with SCLC, using anti-NCAM antibodies. A total of 112 aspirates from 30 chemo-naïve patients were stained, and at multivariate analysis marrow involvement was, as shown previously, an independent factor of unfavorable prognosis. Following chemotherapy, bone marrow became tumor negative only in 25% of initially positive responders and in none of the non-responders.

Bonner et al65 confirmed previous data showing that pretreatment NSE levels are inversely correlated with time to progression and survival in patients with SCLC, being independent prognostic predictors of time to progression and survival. Niho et al66 have compared pro-gastrin-releasing peptide to NSE and carcinoembryonic antigen as a predictor of relapse of SCLC, demonstrating that serum levels of pro-GRP more accurately reflect the disease course of patients with SCLC than the two other markers.

The difficulties in diagnosing accurately N2 disease by using lymph node size on CT scanning alone is emphasized in a study by Takamochi et al,15 especially in patients with a central tumor or a tumor of 40 mm or larger. They recommend a preoperative invasive staging procedure in these populations – a procedure that can be avoided in the populations with normal CT results without any of these risk factors. The question of the timing of a CT scan of the thorax is related to bronchoscopy was investigated by Laroche et al16 who performed a randomized two-group study with all patients undergoing an initial CT staging scan.

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