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By N. P. Johnson, P. Lapetoule, H. Razaka, J. L. Butour (auth.), Marino Nicolini (eds.)

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Extra info for Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy: Proceedings of the Fifth International Symposium on Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy Abano, Padua, ITALY - June 29–July 2, 1987

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Immediately after treatment a certain population of bacteria with monofunctional platinum-DNA lesions may be able to replicate normally to produce colonies with the his phenotype. During 4 h incubation, these monofunctional lesions may evolve into bifunctional DNA adducts which undergo SOS repair, thereby leading to mutations and the reversion to prototrophy. ANTITUMOR ACTIVITY AGAINST L1210 LEUKEMIA Finally we wanted to know whether or not the lesions responsible for the antitumor activity of cisplatin exhibit a similar time-dependent sensitivity to monoadduct quenching as cytotoxicity and the inhibition of replication (Fig.

Velury and R. Sanga BIOCHEMICAL MODULATION OF CISPLATIN ................................ M. Fadool EFFECTS OF CISPLATIN AND CARBOPLATIN ON NEUROHYPOPHYSIS, PARATHYROID AND THEIR ROLE IN NEPHROTOXICITY .................................................................................. A. C Mann, S. B. Howell CISPLATIN UPTAKE MEDIATED CISPLATIN-RESISTANCE IN HUMAN OVARIAN CARCINOMA CELLS ............................................ 248 F. Bernges and E. Holler INTEGRATED POLYMERASE AND EXONUCLEASE ACTIVITIES OF ESCHERICHIA COLI DNA POLYMERASE I ON PLATINATED DNA .............................................................................................................

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