Download Protease Inhibitors as Cancer Chemopreventive Agents by Elizabeth Fontham, Pelayo Correa (auth.), Walter Troll, Ann PDF

By Elizabeth Fontham, Pelayo Correa (auth.), Walter Troll, Ann R. Kennedy (eds.)

Protease inhibitors (PIs) are extensively dispensed in vegetation and animals, and feature numerous features, which come with fighting digestion of seeds by way of bugs and enhancing blood clotting in animals. After it used to be famous that man made and average inhibitors suppress two-stage carcinogenesis and breast melanoma, huge paintings investigating PIs as chemopreventive brokers was once began. PIs are specific in that they intervene with melanoma improvement in quite a few methods, together with suppression of oxygen radicals, oncogenes, and metastases. Epidemiologic proof helps their prevention of significant human cancers in populations that devour meals containing them. Their supervised use in people is at the threshold of improvement. The epidemiologic discovery of the significance of lentils and different seeds wealthy in PIs in combating many human cancers allowed us to examine the motion of PIs as chemopreventive brokers, as reviewed in bankruptcy I (Fontham and Correa). bankruptcy 2 (Kennedy) discusses the position of typical PIs (e. g. , the Bowman-Birk inhibitor) as anticarcinogens and the prospective barriers in their use. In bankruptcy three (Kennedy), the transformation of C3HI lOTlh cells as a result of cancer causing agents and promoters is proven to be suppressed via PIs. Bowman (Chapter four) relates the invention of inhibitors in soybeans which are special from the Kunitz inhibitor, and the prevalence of the same inhibitor in peanuts and different legumes. bankruptcy five (Birk) is an summary of PIs of plant beginning and their function in human nutrition.

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The metaholic pathway hy which rats (chicks and presumably other species responding to soybean- 22 ANN R. , 1983). As soybean protein is known for its deficiency in sulfur-containing amino acids (Liener and Kakade, 1980), rats respond to this food source in a manner unlike that of many species, including humans. , 1982; Soy Protein Council, 1987). Thus, rats are considered an unsuitable species by which to judge the likely effects of soybean protease inhibitors on any organ system, including the pancreas, and the results of studies on soybean products in rats cannot be assumed to represent the likely response of humans to those products.

As there are species, such as the mouse, which respond to soybean protease inhibitors by developing pancreatic hyperplasia and hypertrophy, but do not develop cancer and there are other species, such as the hamster, which respond to soybean protease inhibitors with pancreatic enlargement and a reduced pancreatic cancer risk (Liener and Hasdai, 1986), these phenomena may not be related. Even in rats fed soybean protease inhibitors, the occurrence of hyperplasia/hypertrophy and cancer in the pancreas are separable phenomena (Richter and Schneeman, 1987).

Clair et al. (1990). , 1990b). BBI affected adenomatous tumors of the mouse colon which are histopathologically similar to those which occur in the most common form of human colon cancer. The types of gastrointestinal tract tumors studied are illustrated in Figs. 4-7. , 1990), as shown in Fig. , hyperplasia, as shown in Fig. 9). Oncogenic lesions of the liver are shown in Figs. 10-15. In both the colon and liver carcinogenesis studies, BBI was given in the diet. In the oral carcinogenesis studies performed, BBI was topically applied to the hamster check pouch.

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