Download Rubidomycin: A New Agent against Cancer by J. Bernard, R. Paul, M. Boiron, C. Jacquillat, R. Maral PDF

By J. Bernard, R. Paul, M. Boiron, C. Jacquillat, R. Maral

Trials within the therapy of the leukemias are often in keeping with a speculation, as relating to trade transfusion [33] or using antimetabolites [86]. Or they're carried out empirically because the result of probability observations, as when it comes to using the nitrogen mustards, urethane, and the Vinca alkaloids. Or they lie among the 2, aiming at utilising good confirmed organic proof: examples are using ACTH, cortisone and, extra lately, the antibiotics. what's actual for micro organism can also possibly be precise, if now not for elephants, no less than for the malignant cells of mammals. It was once this concept that lay at the back of the 1st makes an attempt at treating melanoma and leukemia with antibiotics. the implications acquired by way of convinced ingredients extracted from micro-organisms (actinomycin, azaserine, mito­ mycin, rufocromomycin), even though encouraging every now and then, have been inconsistent. The motion of rubidomycin looks to hide a much wider spectrum and to be extra constant and greater. As on the subject of Homer and Christopher Columbus, the distinction of getting given start to rubidomycin is alleged via a couple of kingdom and city. in reality, a similar product was once stumbled on within the similar 12 months, notwithstanding relatively independently, through a gaggle of French employees [184] who defined it less than the identify of rubidomycin, and by means of a bunch of Italian employees [87] who studied it below the identify of daunomycin.

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Extra info for Rubidomycin: A New Agent against Cancer

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The cells were as sensitive to rubidomycin after the 13th passage as the original cells. 25 mg/kg of rubidomycin by the same route, after which rubidomycin was given alone for a further two days. As shown in Table 11, this combined treatment gave slightly better results than those obtained with the antibiotic alone. Table 11. Combined intraperitoneal treatment with "anti-Ehrlich cell" serum and rubidomycin Product No. S. mice, about six weeks old, by means of a trocar. I. = 40%) when administered intravenously, and no activity when administered intraperitoneally and orally (Table 13).

Structure 19 Daunomycin is chemically related to the anthracyclines, such as the rhodomycins, cinerubins, pyrromycins and rutilantins, whose chemistry has been reviewed by BROCKMANN [40]. The numbering system adopted by this author is illustrated in I. Daunomycin is therefore 7-0-(2',3',6' -trideoxy-3' -amino-L-Iyxohexopyranosyl)7,8,9,10-tetrahydro-9-C-acetyl-6,7,9, Il-tetrahydroxy-l-(or 4)-methoxy-5,12-tetracenequlllone. The aglycone and the carbohydrate moieties of daunomycin are easily obtained by mild acid hydrolysis of the antibiotic.

Table 7. 1 Time of sampling 1 day 2 days 3 days 4 days Small areas of epithelial cells Areas of epithelial cells Large areas of epithelial cells Continuous sheet of epithelial cells As for the controls Cells fail develop normally. Few areas of cells. Multinucle:tte cells Degenerate cells: 70 % Normal cells: 30% Degenerate, pyknotic cells. Normal cells: 1% As for the controls As for the controls As for the controls Degenerate cells: 40% Normal cells (including some multinucleate cells): 600(0 to (b) HeLa Cells Characteristic morphological changes were observed in the nucleoli of HeLa cells grown on slides after periods shorter than those for KB cells.

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