By Gail S. Prins Ph.D., Wen-Yang Hu Ph.D. (auth.), Scott D. Cramer (eds.)
Recent facts demonstrates that standard prostate tissue comprises stem cells. there's additionally gathering proof that prostate melanoma incorporates a inhabitants of cells with stem cell-like features known as melanoma stem cells, or tumor starting up cells. either the traditional prostate stem cellphone and melanoma stem mobile populations have very important implications for the new release, healing focusing on, and prevention of prostate melanoma. the aim of this ebook is to discover the position of stem cells in prostate melanoma, that's turning into an more and more scorching pattern in melanoma examine.
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Additional info for Stem Cells and Prostate Cancer
2009; Choi et al. 2012). 1 Evidence for Stem Cells with a Basal Localization The stem cell antigen-1 (Sca-1), a marker of primitive stem/progenitor cells in many adult tissues (Spangrude et al. 1988; Welm et al. 2002; Kim et al. 2005), was used by two different groups to enrich for cells from the mouse prostate capable of tissue regeneration in vivo (Burger et al. 2005; Xin et al. 2005). While Sca-1+ cells, isolated from dissociated adult mouse prostate by FACS, can efficiently regenerate prostatic glands under the renal capsule, Sca-1- cells are devoid of this activity (Xin et al.
Over 6–12 weeks, dissociated cells will regenerate prostatic glands. (b) An alternative approach is in vivo lineage tracing. The Cre recombinase, expressed in a celltype-specific manner, will remove a STOP codon leading to constitutive expression of a reporter protein in the cell type of interest and all of its progeny be physically separated into urogenital sinus mesenchyme (UGSM) and urogenital sinus epithelium (UGSE) and put back together under the renal capsule of immunedeficient mice (Cunha and Lung 1978).
Transgenic Res 20:1073–1086 Ploemacher RE, Brons RH (1989) Separation of CFU-S from primitive cells responsible for reconstitution of the bone marrow hemopoietic stem cell compartment following irradiation: evidence for a pre-CFU-S cell. Exp Hematol 17:263–266 Reynolds BA, Weiss S (1996) Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell. Dev Biol 175:1–13 Richardson GD, Robson CN, Lang SH, Neal DE, Maitland NJ, Collins AT (2004) CD133, a novel marker for human prostatic epithelial stem cells.