By F. M. Huennekens, Y. D. Montejano, K. S. Vitols (auth.), Youcef Rustum, John J. McGuire (eds.)
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Additional resources for The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy
Biophys. Acta. 911:154 (1987). 17. K. I. T. K. H. K. K. M. J. C. Klenk, Measurement of Protein Using Bicinchoninic Acid. Anal. Biochem. 150:76 (1985). -- 18. R. E. MacKenzie, NAD-Dependent Methylenetetrahydrofolate Dehydrogenase Is Expressed by Immortal Cells, ~. BioI. Chem. 260:14616 (1985). 19. M. Trotz, C. Wegner, and H. Nau, Valproic Acid-Induced Neural Tube Defects: Reduction by Folinic Acid in the Mouse, Life Sci. 41: 103 (1987). - - -- 20. A. Straw, D. T. Wynn, Pharmacokinetics of the Diastereoisomers of Leucovorin after Intravenous and Oral Administration to Normal Subjects, Cancer Res.
28:2993 (1979). 23. L. M. Sirotnak, E. L. Kisliuk, Y. Gaumont, and G. Combepine, Further Studies of Stereospecificity at Carbon 6 for Membrane Transport of Tetrahydrofolates, Biochem. Pharmacol. 31:1527 (1982). 36 DISCUSSION OF DR. DUCH'S PRESENTATION Dr. Hines: Have you looked at similar doses of methyltetrahydrofolate, because in man at least, the majority of the CF is converted to methyl. At the high dose levels there may be a different pathway or mechanism and the methylene may be affected more.
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