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By F. M. Huennekens, Y. D. Montejano, K. S. Vitols (auth.), Youcef Rustum, John J. McGuire (eds.)

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Biophys. Acta. 911:154 (1987). 17. K. I. T. K. H. K. K. M. J. C. Klenk, Measurement of Protein Using Bicinchoninic Acid. Anal. Biochem. 150:76 (1985). -- 18. R. E. MacKenzie, NAD-Dependent Methylenetetrahydrofolate Dehydrogenase Is Expressed by Immortal Cells, ~. BioI. Chem. 260:14616 (1985). 19. M. Trotz, C. Wegner, and H. Nau, Valproic Acid-Induced Neural Tube Defects: Reduction by Folinic Acid in the Mouse, Life Sci. 41: 103 (1987). - - -- 20. A. Straw, D. T. Wynn, Pharmacokinetics of the Diastereoisomers of Leucovorin after Intravenous and Oral Administration to Normal Subjects, Cancer Res.

28:2993 (1979). 23. L. M. Sirotnak, E. L. Kisliuk, Y. Gaumont, and G. Combepine, Further Studies of Stereospecificity at Carbon 6 for Membrane Transport of Tetrahydrofolates, Biochem. Pharmacol. 31:1527 (1982). 36 DISCUSSION OF DR. DUCH'S PRESENTATION Dr. Hines: Have you looked at similar doses of methyltetrahydrofolate, because in man at least, the majority of the CF is converted to methyl. At the high dose levels there may be a different pathway or mechanism and the methylene may be affected more.

L. C. Sawyer, R. Nayak, S. W. Young, and T. Woodcock. An overview of thymidine, Cancer 45:11171128 (1980). 5. I. D. Hartman. The effect of 5-fluorouracil on the synthesis and methylation of low molelcular weight nuclear RNA in L1210 cells, Mol. , 17:245-249 (1979). 6. W. P. M. Egan, and E. Loh. 5-Fluoro-2'-Deoxyuridine incorporation into L1210 DNA. J. BioI. , 256:8885-8888 (1981) • 7. V. Danenberg, C. Heidelberger, M. R. Peterson. the incorporation of 5-fluoro-2'-deoxyuridine into dNA of mammalian tumor cells.

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